Mononucleosis—Child Care and Schools

What is mononucleosis?

Mononucleosis (widely known as mono ) is a disease most commonly caused by the Epstein-Barr virus (also called EBV or human herpesvirus 4 ) and sometimes by other viruses such as cytomegalovirus (human herpesvirus 5) and roseola (human herpesvirus 6).

What are the signs or symptoms?

  • Usually mild or no signs or symptoms, especially in young children

  • Fever

  • Sore throat

  • Fatigue and malaise

  • Swollen lymph nodes

  • Temporary enlargement of the liver and spleen for several weeks

  • Rash may occur with those treated with amoxicillin or other penicillin antibiotics. This rash is not an allergy to the antibiotic.

What are the incubation and contagious periods?

  • Incubation period: Estimated to be 30 to 50 days for EBV.

  • Contagious period: Virus is excreted for many months after infection, and virus shedding can occur intermittently throughout life.

How is it spread?

Person-to-person contact

  • Kissing on the mouth

  • Sharing objects contaminated with saliva (eg, toys, toothbrushes, cups, bottles)

  • Semen during sexual contact

  • May be spread by blood transfusion or organ transplant

How do you control it?

  • Use good hand-hygiene technique at all the times listed in Chapter 2 of Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide, 7th Edition .

  • Avoid transfer or contact with saliva (eg, through kissing or sharing respiratory secretions directly or through contact with objects like food utensils, cups, soda cans, and bottles of water).

  • People with signs and symptoms of mononucleosis should not donate blood.

Swollen lymph nodes in a 7-year-old with infectious mononucleosis

AMERICAN ACADEMY OF PEDIATRICS

Profile view of a child's right face, ear, and neck, showing raised round swelling in the jawline and upper neck area, about the size of a baseball, indicating swollen lymph nodes.

What are the roles of the educator and the family?

  • Clean or sanitize surfaces that are touched by hands frequently, such as toys, tables, and doorknobs, according to the Routine Schedule for Cleaning, Sanitizing, and Disinfecting in Chapter 8 of Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide, 7th Edition .

  • Ensure all children have their own toothbrushes, cups, and eating utensils.

  • Prevent children from sharing food.

  • Avoid kissing children on the mouth.

Exclude from educational setting?

No, unless

  • The child is unable to participate and staff members determine they cannot care for the child without compromising their ability to care for the health and safety of the other children in the group.

  • The child meets other exclusion criteria (see Conditions Requiring Temporary Exclusion in Chapter 4 of Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide, 7th Edition ).

Readmit to educational setting?

Yes, when all the following criteria are met:

  • When exclusion criteria are resolved, the child is able to participate, and staff members determine they can care for the child without compromising their ability to care for the health and safety of the other children in the group.

  • School-aged children and adolescents should avoid strenuous activity and contact sports for at least 4 to 6 weeks after symptoms start as the spleen may temporarily enlarge and is at risk of rupture with physical impact. Clearance for contact sports will depend on a health practitioner’s assessment of ongoing symptoms and size of the spleen. It may take 3 to 6 months or longer for a child to regain their full stamina, strength, and fitness.

Comments

  • Most people get the infection in early childhood when signs or symptoms are mild and the disease goes undiagnosed.

  • However, rarely, the disease can be severe, particularly in adolescents. Some individuals might experience ongoing symptoms, such as significant fatigue or malaise, fever, muscle aches, or cognitive fog. These individuals may benefit from class modifications such as adjusted assignments, extended deadlines, or remote learning, depending on the severity of their symptoms.

  • General exclusion of those with mononucleosis is not practical.

Disclaimer

Adapted from Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide , 7th Edition.

The American Academy of Pediatrics (AAP) is an organization of 67,000 primary care pediatricians, pediatric medical subspecialists, and pediatric surgical specialists dedicated to the health, safety, and well-being of all infants, children, adolescents, and young adults.

Any websites, brand names, products, or manufacturers are mentioned for informational and identification purposes only and do not imply an endorsement by the American Academy of Pediatrics (AAP). The AAP is not responsible for the content of external resources. Information was current at the time of publication. The information contained in this publication should not be used as a substitute for the medical care and advice of your pediatrician. There may be variations in treatment that your pediatrician may recommend based on individual facts and circumstances.

Copyright © American Academy of Pediatrics Date Updated: Apr 01 2026 00:00 Version 0.2

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starfish
February 12, 2026
Since February 21, 2026, no new cases of measles have been reported in NC. The NC DHHS no longer recommends early MMR vaccination for infants 6 to 11 months old since there is no sustained transmission currently. While this is welcome news, vaccination rates have dropped in NC and the US. There will likely be further outbreaks in the future. We can give the MMR dose early to families who want it. This applies to infants 6-11 months who have not gotten a dose yet or kids under 4-5 years who have not gotten their second MMR dose. Two doses of the MMR vaccine are highly effective (97%) at preventing measles infections. At CHCAC, children receive their first dose at 12 months of age and a second dose at 4 years of age, ensuring they are fully protected as soon as possible, in accordance with the most up-to-date AAP recommendations. Some infants aged 6 months to 11 months who travel internationally or in high-prevalence areas may need a dose to protect them; however, they still require the 1-year and 4-year-old doses as well. If you are ever concerned about a possible exposure to measles, please CALL before entering our office. DO NOT ENTER the office. NC DHHS keeps a list of areas with measles exposures here . This is a highly contagious illness, and special precautions must be taken to prevent spread. The virus can be present in the air for 2 hours after an infected person is in the room, and 90% of susceptible patients can be infected. As always, if you have questions, we are here to help make sense of it all!