Mononucleosis—Child Care and Schools

What is mononucleosis?

A disease most commonly caused by the Epstein-Barr virus (also called EBV or human herpesvirus 4) and sometimes by other viruses such as cytomegalovirus (human herpesvirus 5) and roseola (human herpesvirus 6); the illness is commonly known as mono.

What are the signs or symptoms?

  • Usually mild or no signs or symptoms, especially in young children.

  • Fever.

  • Sore throat.

  • Fatigue.

  • Swollen lymph nodes.

  • Enlarged liver and spleen.

  • Rash may occur with those treated with ampicillin or other penicillin.

What are the incubation and contagious periods?

  • Incubation period: Estimated to be 30 to 50 days for EBV.

  • Contagious period: Virus is excreted for many months after infection, and virus excretion can occur intermittently throughout life.

How is it spread?

Person-to-person contact

  • Kissing on the mouth

  • Sharing objects contaminated with saliva (eg, toys, toothbrushes, cups, bottles)

  • May be spread by blood transfusion or organ transplantation

How do you control it?

  • Hand hygiene.

  • Avoid transfer or contact with saliva (ie, through kissing or sharing respiratory secretions directly or through contact with objects like food utensils, cups, soda cans, and bottles of water).

  • People with signs and symptoms of mononucleosis should not donate blood.

What are the roles of the teacher/caregiver and the family?

  • Use good hand-hygiene technique at all the times listed in Chapter 2.

  • Clean and sanitize toys and utensils before they are shared (ie, after each child has used them).

  • Ensure all children have their own toothbrushes, cups, and eating utensils.

  • Prevent children from sharing food

  • Avoid kissing children on the mouth.

Exclude from group setting?

No, unless

  • The child is unable to participate and staff members determine they cannot care for the child without compromising their ability to care for the health and safety of the other children in the group.

  • The child meets other exclusion criteria (see Conditions Requiring Temporary Exclusion in Chapter 4).

Readmit to group setting?

Yes, when all the following criteria have been met:

  • When exclusion criteria are resolved, the child is able to participate, and staff members determine they can care for the child without compromising their ability to care for the health and safety of the other children in the group.

  • School-aged children should avoid contact sports if they have an enlarged spleen until the spleen is no longer enlarged.

Comments

  • Most people get the infection in early childhood when signs or symptoms are mild and the disease goes undiagnosed. However, rarely, the disease can be severe, particularly in adolescents.

  • General exclusion of those with mononucleosis is not practical.

Adapted from Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide .

Any websites, brand names, products, or manufacturers are mentioned for informational and identification purposes only and do not imply an endorsement by the American Academy of Pediatrics (AAP). The AAP is not responsible for the content of external resources. Information was current at the time of publication.

The information contained in this publication should not be used as a substitute for the medical care and advice of your pediatrician. There may be variations in treatment that your pediatrician may recommend based on individual facts and circumstances.

Copyright © American Academy of Pediatrics Date Updated: Apr 02 2025 23:15 Version 0.1

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Is Your Child Sick?®

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starfish
February 12, 2026
There have been cases of measles in NC, with exposures in Chapel Hill, Durham, and Wake County. We can give the MMR dose early to families who want it. This applies to infants 6-12 months who have not gotten a dose yet or kids under 4-5 years who have not gotten their second MMR dose. At this time, the NC DHHS and health departments are not recommending this unless traveling or living in an area with sustained transmission. Two doses of the MMR vaccine are highly effective (97%) at preventing measles infections. At CHCAC, children receive their first dose at 12 months of age and a second dose at 4 years of age, ensuring they are fully protected as soon as possible, in accordance with the most up-to-date AAP recommendations. Some infants aged 6 months to 11 months who travel internationally or in high-prevalence areas may need a dose to protect them; however, they still require the 1-year and 4-year-old doses as well. If you are ever concerned about a possible exposure to measles, please CALL before entering our office. DO NOT ENTER the office. NC DHHS keeps a list of areas with measles exposures here . This is a highly contagious illness, and special precautions must be taken to prevent spread. The virus can be present in the air for 2 hours after an infected person is in the room, and 90% of susceptible patients can be infected. As always, if you have questions, we are here to help make sense of it all!